Monoamine transport

Across TCGA cell cohorts, RNA activity of the Monoamine transport pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAB21, HNRNPA0, and SLC4A11, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RAB21 grouped by Monoamine transport-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	RAB21 →	-0.356	-1.319	.001	.001	3	6
SOFT_TISSUE	HNRNPA0 →	-0.230	-1.319	.001	<.001	3	5
SOFT_TISSUE	SLC4A11 →	-0.218	-1.275	<.001	<.001	3	5
OVARY	OR2H1 →	-0.369	-1.324	<.001	<.001	3	5
SOFT_TISSUE	OXTR →	-0.475	-1.816	<.001	<.001	3	4
SOFT_TISSUE	OLIG1 →	-0.349	-1.686	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RAB21 by Monoamine transport activity — SOFT_TISSUE

Explore this box plot interactively →