Monoamine transport

Across TCGA cell cohorts, RNA activity of the Monoamine transport pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CARNMT1, TM9SF2, and H2AC19, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CARNMT1 grouped by Monoamine transport-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CARNMT1 →	-0.579	-1.193	.005	<.001	3	4
LUNG_SCLC	TM9SF2 →	+1.090	+1.022	.006	.005	3	4
SOFT_TISSUE	H2AC19 →	+2.272	+1.693	.002	<.001	3	4
OVARY	GADD45GIP1 →	-0.612	-1.260	.006	.001	3	4
BONE	MBTD1 →	-1.097	-1.571	<.001	.001	3	4
BLOOD_Leukemia	REEP5 →	+0.559	+1.046	.008	.003	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CARNMT1 by Monoamine transport activity — SKIN

Explore this box plot interactively →