Monoamine transport

Across TCGA cell cohorts, RNA activity of the Monoamine transport pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CEP57L1, ENAH, and NQO2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Monoamine transport activity versus CEP57L1 in LARGE_INTESTINE (Pearson r = 0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CEP57L1 →	+1.250	+1.630	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	ENAH →	+0.777	+1.653	.003	<.001	3	4
BLOOD_Myeloma	NQO2 →	+3.056	+0.332	<.001	<.001	3	3
LARGE_INTESTINE	DNAJC8 →	+1.026	+1.336	.001	.003	3	3
LARGE_INTESTINE	KLHL3 →	-0.771	-1.114	.007	.002	2	4
LARGE_INTESTINE	DEPDC1 →	+0.991	+1.000	<.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015844 vs CEP57L1 — LARGE_INTESTINE

Explore this scatter interactively →