Urea transport

Across TCGA patient cohorts, RNA activity of the Urea transport pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are S100A8, S100A9_T113, and AZU1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Urea transport activity versus S100A8 in GBM (Pearson r = 0.46).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	S100A8 →	+1.127	+0.086	<.001	.001	3	8
PDAC	S100A9_T113 →	+1.056	+0.078	<.001	<.001	3	8
HNSC	AZU1 →	+1.107	+0.148	<.001	<.001	3	8
HNSC	MPO →	+1.064	+0.234	<.001	.005	3	8
PDAC	BPI →	+1.094	+0.097	<.001	<.001	3	7
HNSC	PRTN3 →	+0.910	+0.243	<.001	.003	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015840 vs S100A8 — GBM

Explore this scatter interactively →