Urea transport

Across TCGA patient cohorts, RNA activity of the Urea transport pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LINC02169, HNRNPA1P58, and DCDC2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Urea transport activity versus LINC02169 in LUAD (Pearson r = 0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	LINC02169 →	+0.138	+0.655	.003	.002	3	3
CCRCC	HNRNPA1P58 →	+0.493	+0.441	.008	.006	3	3
PDAC	DCDC2 →	+0.991	+0.220	.001	.001	3	3
LSCC	CA4 →	+1.025	+0.882	<.001	.001	3	3
OV	SLC16A1 →	-1.025	-0.791	.001	.002	3	3
UCEC	LRP2BP →	+0.480	+0.714	.009	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015840 vs LINC02169 — LUAD

Explore this scatter interactively →