Amino-acid betaine transport

Across TCGA patient cohorts, RNA activity of the Amino-acid betaine transport pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NCL_S67, DYNLL2, and STMN1_S38, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Amino-acid betaine transport activity versus NCL_S67 in BRCA (Pearson r = -0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	NCL_S67 →	-0.865	-0.062	<.001	<.001	3	7
BRCA	DYNLL2 →	+0.357	+0.053	.001	<.001	3	6
BRCA	STMN1_S38 →	-1.015	-0.055	<.001	<.001	3	6
BRCA	EPB41L1_S75 →	+0.566	+0.038	.004	.003	3	6
COAD	RMDN2 →	+0.379	+0.039	<.001	<.001	3	5
UCEC	RPL30_S10 →	-0.396	-0.058	.003	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015838 vs NCL_S67 — BRCA

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