Amino-acid betaine transport

Across TCGA cell cohorts, RNA activity of the Amino-acid betaine transport pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FHL1, ST6GALNAC6, and CNOT2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FHL1 grouped by Amino-acid betaine transport-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	FHL1 →	+2.671	+1.140	.003	.008	3	4
LIVER	ST6GALNAC6 →	+1.281	+1.824	.004	<.001	3	4
SOFT_TISSUE	CNOT2 →	+0.668	+1.348	.009	.009	3	3
PANCREAS	RNGTT →	+0.734	+1.193	.002	.005	3	3
PANCREAS	PREPL →	+0.913	+1.236	.007	.008	3	3
PANCREAS	RAB6A →	+0.876	+1.700	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FHL1 by Amino-acid betaine transport activity — STOMACH

Explore this box plot interactively →