Amino-acid betaine transport

Across TCGA cell cohorts, RNA activity of the Amino-acid betaine transport pathway is significantly associated with the total protein of multiple features, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are FASN, GATA3, and GSK3-a-b, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Amino-acid betaine transport activity versus FASN in LARGE_INTESTINE (Pearson r = -0.95).

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FASN →	-0.716	-0.101	.010	.041	1	1
LARGE_INTESTINE	GATA3 →	-0.664	-0.101	.044	.041	1	1
LARGE_INTESTINE	GSK3-a-b →	-0.455	-0.101	.030	.041	1	1
LARGE_INTESTINE	HER3_pY1289 →	+0.348	+0.101	.040	.041	1	1
LARGE_INTESTINE	MAPK_pT202_Y204 →	-1.223	-0.101	.030	.041	1	1
LARGE_INTESTINE	MEK1_p_S217_S221 →	-1.089	-0.101	.026	.041	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015838 vs FASN — LARGE_INTESTINE

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