Amino-acid betaine transport

Across TCGA cell cohorts, RNA activity of the Amino-acid betaine transport pathway is significantly associated with the drug response of multiple features, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are SB216763, Doramapimod, and SGC-CBP30, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SB216763 grouped by Amino-acid betaine transport-low versus -high activity in LARGE_INTESTINE.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SB216763 →	-0.680	-0.101	.049	.041	1	1
LARGE_INTESTINE	Doramapimod →	-0.349	-0.101	.011	.041	1	1
LARGE_INTESTINE	SGC-CBP30 →	-0.300	-0.101	.042	.041	1	1
LARGE_INTESTINE	Entinostat →	-0.785	-0.101	.023	.041	1	1
LARGE_INTESTINE	PFI3 →	-0.219	-0.101	.005	.041	1	1
LARGE_INTESTINE	Wnt-C59 →	-0.709	-0.101	.023	.041	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SB216763 by Amino-acid betaine transport activity — LARGE_INTESTINE

Explore this box plot interactively →