Peptide transport

Across TCGA patient cohorts, RNA activity of the Peptide transport pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CPE, MCM4, and NAA50, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peptide transport activity versus CPE in PDAC (Pearson r = 0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	CPE →	+0.730	+0.034	<.001	<.001	3	6
BRCA	MCM4 →	-0.499	-0.019	.001	<.001	3	5
BRCA	NAA50 →	-0.247	-0.019	.001	<.001	3	5
COAD	NRDC →	-0.237	-0.021	<.001	<.001	3	5
GBM	EFTUD2 →	-0.282	-0.039	.001	<.001	3	5
LUAD	ATF7IP_S445 →	-0.239	-0.013	.004	.005	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015833 vs CPE — PDAC

Explore this scatter interactively →