Peptide transport

Across TCGA patient cohorts, RNA activity of the Peptide transport pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PKIB, GLUL, and CDCA7, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peptide transport activity versus PKIB in COAD (Pearson r = -0.02).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PKIB →	+0.860	+0.069	<.001	.005	3	2
COAD	GLUL →	+0.429	+0.066	.002	.008	3	2
BRCA	CDCA7 →	-2.476	-1.143	.002	.003	3	2
COAD	MIER3 →	+0.324	+0.095	<.001	<.001	3	2
COAD	PTGDR →	+0.746	+0.109	<.001	.001	3	2
COAD	PTGER4 →	+0.776	+0.147	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015833 vs PKIB — COAD

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