Peptide transport

Across TCGA cell cohorts, RNA activity of the Peptide transport pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPP1R18, ARL6, and GATC, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peptide transport activity versus PPP1R18 in STOMACH (Pearson r = 0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	PPP1R18 →	+1.850	+0.282	.002	<.001	3	4
LUNG_NSCLC_LUSC	ARL6 →	-0.922	-0.213	.003	.001	2	5
LUNG_NSCLC_LUSC	GATC →	-0.829	-0.268	<.001	.002	3	4
OESOPHAGUS	RPL7 →	-0.651	-0.219	<.001	.003	3	4
UPPER_AERODIGESTIVE_TRACT	TAP1 →	+1.375	+0.285	.008	.002	2	5
URINARY_TRACT	EDA →	-0.222	-0.259	.006	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015833 vs PPP1R18 — STOMACH

Explore this scatter interactively →