Tryptophan transport

Across TCGA patient cohorts, RNA activity of the Tryptophan transport pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SLC3A2, TP53BP1_S1028, and IMPDH1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Tryptophan transport activity versus SLC3A2 in LSCC (Pearson r = 0.55).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SLC3A2 →	+0.589	+0.113	<.001	<.001	3	6
LUAD	TP53BP1_S1028 →	+0.313	+0.076	.005	.001	3	6
CCRCC	IMPDH1 →	+0.284	+0.065	<.001	<.001	3	6
UCEC	KIDINS220_S1555 →	+0.720	+0.085	<.001	.008	3	6
HNSC	EIF4E3 →	-0.386	-0.093	<.001	<.001	3	5
BRCA	RAF1 →	-0.168	-0.054	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015827 vs SLC3A2 — LSCC

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