Tryptophan transport

Across TCGA patient cohorts, RNA activity of the Tryptophan transport pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANXA2P1, AGR3, and KCNK1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Tryptophan transport activity versus ANXA2P1 in OV (Pearson r = 0.09).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ANXA2P1 →	+2.194	+0.202	.003	.008	3	4
BRCA	AGR3 →	-2.604	-0.550	.001	.001	3	4
GBM	KCNK1 →	+0.963	+0.794	.004	<.001	3	4
HNSC	PTGER2 →	-0.665	-0.349	<.001	.006	3	3
COAD	SPATA18 →	-0.873	-0.713	<.001	.001	3	3
HNSC	EMB →	-0.863	-0.276	<.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015827 vs ANXA2P1 — OV

Explore this scatter interactively →