Tryptophan transport

Across TCGA patient cohorts, RNA activity of the Tryptophan transport pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RAB44_S411, SLC3A2, and SLC7A8_T522, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Tryptophan transport activity versus RAB44_S411 in BRCA (Pearson r = -0.53).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RAB44_S411 →	-1.055	-1.462	.002	<.001	3	3
OV	SLC3A2 →	+0.846	+0.252	.007	.006	1	5
LSCC	SLC7A8_T522 →	+1.967	+0.804	<.001	<.001	3	3
LSCC	CABLES1_S290 →	-0.652	-1.508	.001	<.001	3	3
GBM	RUNX1_S21 →	-0.411	-0.993	<.001	<.001	3	3
PDAC	SLC25A51 →	+0.434	+0.422	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015827 vs RAB44_S411 — BRCA

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