Tryptophan transport

Across TCGA cell cohorts, RNA activity of the Tryptophan transport pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTOV1, GRPEL1, and SCO1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PTOV1 grouped by Tryptophan transport-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	PTOV1 →	-0.635	-0.974	.001	<.001	3	4
BLOOD_Myeloma	GRPEL1 →	+0.996	+1.478	.001	.001	3	4
BLOOD_Myeloma	SCO1 →	+1.181	+1.478	<.001	.001	3	4
BLOOD_Myeloma	TSR1 →	+1.230	+1.478	.003	.001	3	4
CNS	IL22RA1 →	+0.558	+0.803	.002	.002	3	4
SKIN	EFCAB13 →	-0.944	-1.051	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PTOV1 by Tryptophan transport activity — OVARY

Explore this box plot interactively →