L-serine transport

Across TCGA cell cohorts, RNA activity of the L-serine transport pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDLIM4, HPX, and MRPL42, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PDLIM4 grouped by L-serine transport-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	PDLIM4 →	+3.156	+1.627	.007	<.001	2	6
OESOPHAGUS	HPX →	-0.472	-1.262	.009	.002	3	4
CNS	MRPL42 →	+0.404	+0.991	.004	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	RMDN2 →	+1.289	+1.523	.002	.001	3	4
UPPER_AERODIGESTIVE_TRACT	VPS11 →	+1.172	+1.730	.001	<.001	3	4
STOMACH	SGO1 →	+1.034	+1.418	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PDLIM4 by L-serine transport activity — KIDNEY

Explore this box plot interactively →