L-serine transport

Across TCGA cell cohorts, RNA activity of the L-serine transport pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AHNAK2, FAM117B, and DYSF, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, L-serine transport activity versus AHNAK2 in LIVER (Pearson r = 0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	AHNAK2 →	+3.845	+0.228	.008	.002	3	6
BLOOD_Myeloma	FAM117B →	-0.760	-0.430	.001	<.001	3	6
LIVER	DYSF →	+3.161	+0.196	<.001	<.001	3	5
LARGE_INTESTINE	SMAD3 →	+1.292	+0.251	.004	.004	3	5
LARGE_INTESTINE	PDLIM7 →	+1.407	+0.277	.002	.002	3	5
LUNG_SCLC	SHD →	-2.096	-0.266	.006	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015825 vs AHNAK2 — LIVER

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