Proline transport

Across TCGA patient cohorts, RNA activity of the Proline transport pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SLC1A4, RSL1D1, and SLC3A2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Proline transport activity versus SLC1A4 in LSCC (Pearson r = 0.56).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SLC1A4 →	+0.850	+0.078	<.001	<.001	3	5
GBM	RSL1D1 →	+0.352	+0.061	.001	.006	3	5
LSCC	SLC3A2 →	+0.605	+0.087	<.001	.001	3	5
PDAC	FYTTD1_S23 →	-0.607	-0.063	.003	<.001	3	5
GBM	ABLIM2 →	-0.408	-0.082	<.001	<.001	3	5
PDAC	LOXL2 →	+0.801	+0.055	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015824 vs SLC1A4 — LSCC

Explore this scatter interactively →