Proline transport

Across TCGA patient cohorts, RNA activity of the Proline transport pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYOCD, ZNF397, and NUDT16, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Proline transport activity versus MYOCD in LUAD (Pearson r = -0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MYOCD →	-0.662	-0.768	<.001	<.001	3	5
BRCA	ZNF397 →	-0.303	-0.490	.008	<.001	3	4
COAD	NUDT16 →	-0.349	-0.347	.003	.004	3	4
HNSC	CAND2 →	-1.012	-0.716	<.001	.003	3	4
LUAD	ABI3BP →	-0.747	-0.612	.003	.001	3	4
HNSC	SCIMP →	-0.614	-0.641	.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015824 vs MYOCD — LUAD

Explore this scatter interactively →