Ornithine transport

Across TCGA patient cohorts, RNA activity of the Ornithine transport pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PSMB7, DENND4B_S736, and FAM110C_S202, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ornithine transport activity versus PSMB7 in LUAD (Pearson r = 0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PSMB7 →	+0.233	+0.055	<.001	<.001	3	4
PDAC	DENND4B_S736 →	+0.335	+0.043	.008	.007	3	4
LSCC	FAM110C_S202 →	-1.009	-0.062	.001	<.001	3	4
PDAC	RBX1 →	+0.243	+0.061	<.001	.001	3	4
LUAD	TTC38 →	-0.315	-0.046	.001	.004	3	3
LUAD	UBA7 →	-0.202	-0.060	.007	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015822 vs PSMB7 — LUAD

Explore this scatter interactively →