Ornithine transport

Across TCGA cell cohorts, RNA activity of the Ornithine transport pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TLE4, TRIM7, and MPP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ornithine transport activity versus TLE4 in CNS (Pearson r = 0.74).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	TLE4 →	+2.071	+1.685	.006	<.001	2	4
OESOPHAGUS	TRIM7 →	+1.387	+1.202	<.001	.001	3	3
BONE	MPP1 →	+1.639	+1.798	.001	.002	3	3
SKIN	CACHD1 →	-1.041	-0.422	.002	.009	2	4
OESOPHAGUS	APPBP2 →	-0.820	-1.149	.008	.003	3	2
OESOPHAGUS	FARP2 →	-0.997	-1.436	.007	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015822 vs TLE4 — CNS

Explore this scatter interactively →