L-leucine transport

Across TCGA patient cohorts, RNA activity of the L-leucine transport pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are C1orf35, DOCK11, and DAB2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, L-leucine transport activity versus C1orf35 in LSCC (Pearson r = -0.44).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	C1orf35 →	-0.323	-0.060	<.001	<.001	3	8
GBM	DOCK11 →	+0.397	+0.059	<.001	<.001	3	7
GBM	DAB2 →	+0.611	+0.053	<.001	<.001	3	7
GBM	MRC1 →	+0.807	+0.062	<.001	<.001	3	7
GBM	PLEKHO2 →	+0.281	+0.053	<.001	<.001	3	7
BRCA	POLR1E →	-0.333	-0.044	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015820 vs C1orf35 — LSCC

Explore this scatter interactively →