L-leucine transport

Across TCGA patient cohorts, RNA activity of the L-leucine transport pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HSPE1P13, KLK10, and DMTN, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, L-leucine transport activity versus HSPE1P13 in COAD (Pearson r = -0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	HSPE1P13 →	-0.174	-0.459	.008	.001	2	4
LUAD	KLK10 →	+0.928	+0.579	.001	.001	3	3
LUAD	DMTN →	+0.556	+0.570	.003	.003	3	3
HNSC	KCNMA1-AS2 →	-0.630	-0.730	.002	<.001	3	3
GBM	CEBPA →	+0.630	+0.693	.003	<.001	3	3
OV	CPNE9 →	-0.357	-0.445	.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015820 vs HSPE1P13 — COAD

Explore this scatter interactively →