L-leucine transport

Across TCGA cell cohorts, RNA activity of the L-leucine transport pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KDM1A, THAP2, and FRAS1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KDM1A grouped by L-leucine transport-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	KDM1A →	+0.983	+1.217	<.001	.001	3	5
URINARY_TRACT	THAP2 →	+1.763	+1.792	.002	<.001	3	4
LIVER	FRAS1 →	+2.649	+1.419	.001	.001	3	4
BLOOD_Leukemia	LONRF1 →	+1.272	+1.139	.007	.004	3	4
LIVER	SLC11A1 →	+0.088	+1.840	.001	<.001	3	4
OVARY	KLHL5 →	+1.139	+1.378	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KDM1A by L-leucine transport activity — BLOOD_Leukemia

Explore this box plot interactively →