Glycine transport

Across TCGA patient cohorts, RNA activity of the Glycine transport pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are USP48, NNMT, and SERPINH1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glycine transport activity versus USP48 in GBM (Pearson r = -0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	USP48 →	-0.287	-0.094	<.001	<.001	3	7
OV	NNMT →	+0.891	+0.053	.005	.002	3	6
LSCC	SERPINH1 →	+0.495	+0.096	<.001	<.001	3	6
LSCC	TNKS1BP1_S836 →	+0.644	+0.090	<.001	.001	3	6
LSCC	FAP →	+0.706	+0.079	<.001	.006	3	6
BRCA	MRC2 →	+0.563	+0.055	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015816 vs USP48 — GBM

Explore this scatter interactively →