Glycine transport

Across TCGA cell cohorts, RNA activity of the Glycine transport pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PYGO2, DDI2, and MT-ND1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PYGO2 grouped by Glycine transport-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	PYGO2 →	+0.594	+1.021	.001	.003	3	4
OESOPHAGUS	DDI2 →	+0.574	+0.712	.007	.005	3	4
SKIN	MT-ND1 →	+0.893	+1.228	<.001	<.001	3	4
BLOOD_Leukemia	TGIF2 →	+0.634	+1.270	.004	<.001	3	4
BLOOD_Leukemia	EFNA1 →	+1.051	+0.924	.002	.001	2	5
BLOOD_Leukemia	MPI →	+0.855	+1.118	.004	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PYGO2 by Glycine transport activity — CNS

Explore this box plot interactively →