L-glutamate transmembrane transport

Across TCGA patient cohorts, RNA activity of the L-glutamate transmembrane transport pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NAMPT, DDAH2, and GABPA, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, L-glutamate transmembrane transport activity versus NAMPT in LUAD (Pearson r = 0.15).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	NAMPT →	+0.795	+0.061	<.001	<.001	3	5
PDAC	DDAH2 →	-0.414	-0.059	<.001	<.001	3	5
GBM	GABPA →	-0.388	-0.071	<.001	<.001	3	5
HNSC	HDGFL3 →	-0.387	-0.056	.009	.002	3	5
LSCC	MBOAT2_T474 →	+0.682	+0.066	.004	<.001	3	5
OV	THOP1 →	+0.265	+0.041	.005	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015813 vs NAMPT — LUAD

Explore this scatter interactively →