L-glutamate transmembrane transport

Across TCGA cell cohorts, RNA activity of the L-glutamate transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UNC5CL, NRCAM, and KLF5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, UNC5CL grouped by L-glutamate transmembrane transport-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	UNC5CL →	-0.772	-1.216	.009	.003	3	5
LUNG_NSCLC_LUAD	NRCAM →	-1.632	-0.593	.003	.006	3	4
SOFT_TISSUE	KLF5 →	-2.511	-0.454	<.001	.003	2	5
LUNG_NSCLC_LUSC	ATG4D →	-0.986	-0.593	.002	<.001	3	4
LUNG_NSCLC_LUSC	GPX2 →	-6.928	-0.486	.003	<.001	3	4
BONE	DGAT1 →	-1.519	-1.412	.003	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

UNC5CL by L-glutamate transmembrane transport activity — PANCREAS

Explore this box plot interactively →