L-glutamate transmembrane transport

Across TCGA cell cohorts, RNA activity of the L-glutamate transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STX10, LONP1, and SLC9A6, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, L-glutamate transmembrane transport activity versus STX10 in LARGE_INTESTINE (Pearson r = -0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	STX10 →	-0.788	-0.854	.003	.004	3	5
STOMACH	LONP1 →	-1.130	-1.312	.001	.006	3	4
BLOOD_Lymphoma	SLC9A6 →	+0.629	+0.908	.003	.008	3	4
OESOPHAGUS	ISOC2 →	+0.632	+0.590	<.001	.001	3	3
OESOPHAGUS	PPP2R3A →	+1.151	+0.778	.002	.006	3	3
KIDNEY	HCFC2 →	+0.808	+0.343	.006	.003	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015813 vs STX10 — LARGE_INTESTINE

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