L-cystine transport

Across TCGA patient cohorts, RNA activity of the L-cystine transport pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HMGN4, HSPA4L, and SLC7A5, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, L-cystine transport activity versus HMGN4 in UCEC (Pearson r = -0.17).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HMGN4 →	-0.529	-0.113	.001	<.001	3	7
COAD	HSPA4L →	+0.659	+0.071	<.001	<.001	3	6
BRCA	SLC7A5 →	+0.709	+0.052	<.001	<.001	3	6
LUAD	USP10_S547 →	+0.665	+0.110	.001	.007	3	6
HNSC	CLUH →	+0.388	+0.199	<.001	<.001	3	6
LUAD	DDAH1 →	-0.485	-0.105	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015811 vs HMGN4 — UCEC

Explore this scatter interactively →