L-cystine transport

Across TCGA patient cohorts, RNA activity of the L-cystine transport pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC7A11, CD1D, and TBC1D2B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, L-cystine transport activity versus SLC7A11 in LSCC (Pearson r = 0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SLC7A11 →	+2.621	+1.150	<.001	<.001	3	5
LSCC	CD1D →	-0.624	-1.029	<.001	<.001	3	5
HNSC	TBC1D2B →	-0.551	-0.427	<.001	.008	3	5
HNSC	LILRB1 →	-0.916	-0.515	<.001	.004	3	4
HNSC	JAK3 →	-0.871	-0.466	<.001	.001	3	4
HNSC	CLEC4A →	-0.659	-0.704	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015811 vs SLC7A11 — LSCC

Explore this scatter interactively →