L-cystine transport

Across TCGA cell cohorts, RNA activity of the L-cystine transport pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC3A1, SLC7A9, and SLC7A11, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC3A1 grouped by L-cystine transport-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SLC3A1 →	-0.516	-1.082	<.001	.004	3	11
BLOOD_Leukemia	SLC7A9 →	-0.321	-1.137	<.001	.002	2	8
KIDNEY	SLC7A11 →	-0.398	-1.407	.001	.003	3	5
KIDNEY	ZNF786 →	-0.336	-1.500	<.001	<.001	2	6
BREAST	SLC7A13 →	-0.251	-1.159	<.001	<.001	3	5
PANCREAS	CPLANE2 →	-0.263	-1.773	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC3A1 by L-cystine transport activity — BLOOD_Leukemia

Explore this box plot interactively →