Aspartate transmembrane transport

Across TCGA patient cohorts, RNA activity of the Aspartate transmembrane transport pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are THEMIS2, THEMIS2_T593, and FYB1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Aspartate transmembrane transport activity versus THEMIS2 in BRCA (Pearson r = 0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	THEMIS2 →	+0.441	+0.051	<.001	<.001	3	8
HNSC	THEMIS2_T593 →	+0.583	+0.080	<.001	<.001	3	8
GBM	FYB1 →	+0.627	+0.047	<.001	<.001	3	8
HNSC	LAP3 →	+0.518	+0.069	<.001	<.001	3	8
GBM	LCP1 →	+0.563	+0.054	.001	<.001	3	8
GBM	PARVG →	+0.616	+0.084	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015810 vs THEMIS2 — BRCA

Explore this scatter interactively →