Aspartate transmembrane transport

Across TCGA patient cohorts, RNA activity of the Aspartate transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LINC02884, CRTAM, and MS4A1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Aspartate transmembrane transport activity versus LINC02884 in UCEC (Pearson r = -0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LINC02884 →	-0.631	-0.425	.001	.004	3	5
OV	CRTAM →	-0.559	-0.242	.003	<.001	3	5
OV	MS4A1 →	-1.944	-0.315	.001	<.001	3	5
OV	CCL19 →	-2.631	-0.242	<.001	.003	3	5
HNSC	CHRDL1 →	-1.028	-0.181	.003	.005	3	5
HNSC	ANK2 →	-0.941	-0.264	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015810 vs LINC02884 — UCEC

Explore this scatter interactively →