Aspartate transmembrane transport

Across TCGA cell cohorts, RNA activity of the Aspartate transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACTB, TRAM2, and UBC, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ACTB grouped by Aspartate transmembrane transport-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	ACTB →	-0.827	-0.960	.003	.006	3	5
UPPER_AERODIGESTIVE_TRACT	TRAM2 →	-1.881	-1.218	.001	<.001	3	5
URINARY_TRACT	UBC →	-1.102	-1.423	.001	.008	3	4
URINARY_TRACT	TRIM13 →	+1.115	+1.309	.005	.007	3	4
URINARY_TRACT	RAB18 →	-0.719	-1.759	<.001	.003	3	4
LUNG_NSCLC_LUAD	SEMA3C →	-1.423	-0.628	<.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ACTB by Aspartate transmembrane transport activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →