Aspartate transmembrane transport

Across TCGA cell cohorts, RNA activity of the Aspartate transmembrane transport pathway is significantly associated with the protein abundance of multiple proteins, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SLC25A13, RAN, and CACYBP, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Aspartate transmembrane transport activity versus SLC25A13 in OVARY (Pearson r = 0.56).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	SLC25A13 →	+1.460	+0.471	<.001	.003	3	14
OVARY	RAN →	-0.492	-0.346	.008	.003	3	10
LUNG_NSCLC_LUAD	CACYBP →	-0.702	-0.179	.002	.007	3	9
LUNG_SCLC	SLC25A12 →	+0.911	+0.638	<.001	.001	3	8
OVARY	CRK →	-1.568	-0.600	.006	.008	3	8
OVARY	EDF1 →	-1.336	-0.354	<.001	.002	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015810 vs SLC25A13 — OVARY

Explore this scatter interactively →