L-alanine transport

Across TCGA patient cohorts, RNA activity of the L-alanine transport pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AOX1, SLC1A4, and RSPO1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, L-alanine transport activity versus AOX1 in LSCC (Pearson r = -0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	AOX1 →	-0.512	-0.252	.001	.001	3	5
BRCA	SLC1A4 →	+0.955	+0.427	<.001	<.001	2	5
OV	RSPO1 →	-1.439	-0.144	.006	.001	3	4
LUAD	MAPK6P6 →	+0.026	+0.456	.009	.007	3	4
GBM	SERPING1 →	-0.713	-0.577	.006	.003	3	4
LSCC	MIR1289-2 →	+0.913	+0.257	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015808 vs AOX1 — LSCC

Explore this scatter interactively →