L-alanine transport

Across TCGA cell cohorts, RNA activity of the L-alanine transport pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EMP1, AP2B1, and ZKSCAN2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EMP1 grouped by L-alanine transport-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	EMP1 →	-2.471	-1.038	.001	<.001	3	4
OESOPHAGUS	AP2B1 →	+0.909	+1.147	.001	.002	2	5
LUNG_NSCLC_LUAD	ZKSCAN2 →	+0.498	+0.890	.003	.002	3	4
UPPER_AERODIGESTIVE_TRACT	NPHP1 →	+1.026	+1.242	.002	.008	2	5
BLOOD_Lymphoma	BCL10 →	+0.748	+1.538	.002	<.001	2	4
BLOOD_Lymphoma	TMEM138 →	+1.059	+1.538	.009	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EMP1 by L-alanine transport activity — BREAST

Explore this box plot interactively →