L-alanine transport

Across TCGA cell cohorts, RNA activity of the L-alanine transport pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SFXN1, TMEM251, and C1QL4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, L-alanine transport activity versus SFXN1 in BREAST (Pearson r = 0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	SFXN1 →	+1.155	+0.164	<.001	.005	3	6
SKIN	TMEM251 →	+0.823	+0.185	.003	.003	3	5
SKIN	C1QL4 →	+0.734	+0.224	<.001	<.001	3	4
OESOPHAGUS	TUT1 →	+0.908	+0.106	.006	<.001	3	4
BLOOD_Myeloma	RNASE4 →	+2.200	+0.309	.001	.006	3	4
LUNG_NSCLC_LUAD	CORO2A →	-1.292	-0.163	.003	.003	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015808 vs SFXN1 — BREAST

Explore this scatter interactively →