L-amino acid transport

Across TCGA patient cohorts, RNA activity of the L-amino acid transport pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RCN3, AMPD3, and FTL, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, L-amino acid transport activity versus RCN3 in COAD (Pearson r = 0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RCN3 →	+0.577	+0.033	<.001	<.001	3	7
GBM	AMPD3 →	+0.537	+0.045	<.001	<.001	3	7
GBM	FTL →	+0.928	+0.045	<.001	<.001	3	7
GBM	ARHGAP4 →	+0.379	+0.043	.004	<.001	3	7
LSCC	BTK →	+0.431	+0.048	.002	<.001	3	7
OV	C1S →	+0.547	+0.038	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015807 vs RCN3 — COAD

Explore this scatter interactively →