L-amino acid transport

Across TCGA cell cohorts, RNA activity of the L-amino acid transport pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDKN1A, TP53BP2, and SFXN3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CDKN1A grouped by L-amino acid transport-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	CDKN1A →	-2.672	-1.084	.003	.002	3	4
STOMACH	TP53BP2 →	-0.638	-1.442	.001	<.001	3	4
LIVER	SFXN3 →	-1.767	-1.116	.006	.002	3	3
LIVER	TPM1 →	-2.463	-1.341	.007	<.001	3	3
LIVER	FAXC →	-1.280	-1.392	.005	<.001	2	4
URINARY_TRACT	ATP6V0D1 →	-1.519	-1.744	.007	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CDKN1A by L-amino acid transport activity — OVARY

Explore this box plot interactively →