L-amino acid transport

Across TCGA cell cohorts, RNA activity of the L-amino acid transport pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYB, PSORS1C1, and SLC43A1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, L-amino acid transport activity versus MYB in LARGE_INTESTINE (Pearson r = -0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MYB →	-2.281	-0.289	.001	<.001	3	8
STOMACH	PSORS1C1 →	+2.181	+0.471	.002	.003	3	7
STOMACH	SLC43A1 →	-3.611	-0.353	<.001	.003	3	6
BLOOD_Myeloma	CENPV →	-3.034	-0.366	.002	.005	2	7
BONE	ATP6AP2 →	+1.546	+0.508	<.001	.001	3	6
BONE	NELFA →	-0.863	-0.436	.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015807 vs MYB — LARGE_INTESTINE

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