Branched-chain amino acid transport

Across TCGA patient cohorts, RNA activity of the Branched-chain amino acid transport pathway is significantly associated with the RNA expression of multiple genes, with the LAML cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FGD2, SLC7A7, and IL12RB1, each associated with the pathway in up to 25 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Branched-chain amino acid transport activity versus FGD2 in LAML (Pearson r = 0.63).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LAML	FGD2 →	+1.948	+0.086	<.001	<.001	3	25
LAML	SLC7A7 →	+1.962	+0.097	<.001	<.001	3	24
SARC	IL12RB1 →	+0.823	+0.021	<.001	<.001	3	24
SARC	MYO1F →	+0.799	+0.019	<.001	<.001	3	23
ESCA	TMEM150B →	+1.733	+0.079	<.001	<.001	3	23
CESC	PREX1 →	+0.787	+0.031	<.001	<.001	3	23

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015803 vs FGD2 — LAML

Explore this scatter interactively →