Branched-chain amino acid transport

Across TCGA patient cohorts, RNA activity of the Branched-chain amino acid transport pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PLCB2, RNASE6, and STK10, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Branched-chain amino acid transport activity versus PLCB2 in GBM (Pearson r = 0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PLCB2 →	+0.408	+0.053	<.001	<.001	3	8
LSCC	RNASE6 →	+0.408	+0.050	<.001	<.001	3	6
LSCC	STK10 →	+0.365	+0.061	<.001	<.001	3	6
OV	STK10_S514 →	+0.952	+0.052	<.001	<.001	3	6
GBM	WAS →	+0.514	+0.063	<.001	<.001	3	6
LSCC	WIPF1 →	+0.296	+0.054	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015803 vs PLCB2 — GBM

Explore this scatter interactively →