Branched-chain amino acid transport

Across TCGA cell cohorts, RNA activity of the Branched-chain amino acid transport pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC6A14, SLC7A7, and SLC6A17, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC6A14 grouped by Branched-chain amino acid transport-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	SLC6A14 →	-0.371	-1.601	<.001	<.001	3	7
SKIN	SLC7A7 →	-0.213	-1.042	<.001	<.001	3	6
CNS	SLC6A17 →	-0.281	-1.387	<.001	<.001	3	5
BLOOD_Leukemia	MEIS1 →	+0.339	+1.216	.003	.006	3	4
CNS	SLC6A20 →	-0.180	-1.207	.005	<.001	3	4
BONE	CHST7 →	-0.217	-1.446	.005	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC6A14 by Branched-chain amino acid transport activity — OVARY

Explore this box plot interactively →