Branched-chain amino acid transport

Across TCGA cell cohorts, RNA activity of the Branched-chain amino acid transport pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DEPDC1B, TXLNA, and LIMS3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DEPDC1B grouped by Branched-chain amino acid transport-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	DEPDC1B →	+1.188	+1.613	<.001	<.001	3	5
BLOOD_Leukemia	TXLNA →	+0.836	+1.189	.001	.005	3	5
PANCREAS	LIMS3 →	+0.903	+0.679	.002	.003	3	4
CNS	POLR3B →	+0.690	+1.087	.001	.002	3	4
BLOOD_Leukemia	COA7 →	+0.884	+1.285	<.001	<.001	3	4
CNS	NADK →	+0.514	+0.968	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DEPDC1B by Branched-chain amino acid transport activity — BLOOD_Leukemia

Explore this box plot interactively →