Branched-chain amino acid transport

Across TCGA cell cohorts, RNA activity of the Branched-chain amino acid transport pathway is significantly associated with the shRNA dependency of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZBTB26, SMARCD2, and TNFRSF11B, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZBTB26 grouped by Branched-chain amino acid transport-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	ZBTB26 →	-0.089	-0.152	.009	.001	3	5
BLOOD_Lymphoma	SMARCD2 →	+0.426	+0.202	.006	.009	2	6
OVARY	TNFRSF11B →	-0.177	-0.121	.007	.002	3	4
URINARY_TRACT	AKT1S1 →	+0.222	+0.214	.005	.002	3	4
OESOPHAGUS	SOX2 →	+0.162	+0.136	<.001	.002	3	4
BLOOD_Myeloma	PFKFB3 →	-0.195	-0.162	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZBTB26 by Branched-chain amino acid transport activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →