Branched-chain amino acid transport

Across TCGA cell cohorts, RNA activity of the Branched-chain amino acid transport pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC7A5, SLC3A2, and ANXA8, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Branched-chain amino acid transport activity versus SLC7A5 in PANCREAS (Pearson r = 0.73).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	SLC7A5 →	+2.424	+0.347	<.001	<.001	3	8
OVARY	SLC3A2 →	+1.853	+0.345	.002	<.001	3	7
LUNG_NSCLC_LUAD	ANXA8 →	+2.013	+0.227	.009	.006	3	5
URINARY_TRACT	ATG101 →	+0.521	+0.394	.001	.003	3	4
URINARY_TRACT	RNF128 →	-5.520	-0.544	<.001	.006	3	4
OESOPHAGUS	ANXA8L1 →	+4.446	+0.375	.008	.002	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015803 vs SLC7A5 — PANCREAS

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