Basic amino acid transport

Across TCGA patient cohorts, RNA activity of the Basic amino acid transport pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SERPINB10, ACP5, and MMP9, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Basic amino acid transport activity versus SERPINB10 in BRCA (Pearson r = 0.17).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SERPINB10 →	+0.823	+0.038	.002	<.001	3	5
LSCC	ACP5 →	+0.437	+0.054	.001	<.001	3	5
GBM	MMP9 →	+0.940	+0.044	<.001	<.001	3	5
GBM	S100A12 →	+1.095	+0.040	<.001	<.001	3	5
LSCC	FCN1 →	+0.763	+0.060	.001	<.001	3	5
BRCA	SRPRA →	+0.218	+0.024	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015802 vs SERPINB10 — BRCA

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